Generic Name: Cefuroxime Axetil 250mg + Clavulanic Acid 62.5mg
Manufacturer/Distributor: Orion Pharmaceuticals Ltd.
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Indications of Co-axet 250 Tablet
(injectable to oral)
Pharmacology of Co-axet 250 Tablet
Cefuroxime is a bactericidal second-generation cephalosporin antibiotic that kills a wide spectrum of Gram-positive and Gram-negative bacteria, including many beta-lactamase-producing strains. Cefuroxime works by interfering with the transpeptidation process, which stops bacteria from making cell walls.
Streptomyces clavuligerus produces clavulanic acid, a naturally derived beta-lactamase inhibitor. It has a structure comparable to beta-lactam antibiotics, and it binds to beta-lactamase enzymes and inactivates them irreversibly. Clavulanic acid protects Cefuroxime against breakdown by beta-lactamase enzymes, making it a viable therapy option for bacterial infections.
Co-axet 250 Tablet Dosage & Administration
Adolescents and adults (13 years and older)-
Paediatric Patients (3 months to 12 years)-
Interaction
The area under the serum concentration versus time curve increases by 50% when probenecid and Cefuroxime-Clavulanic Acid are given together. A drug that lowers stomach acidity may impair Cefuroxime bioavailability and neutralize the impact of postprandial absorption.
Contraindications
Cefuroxime-Clavulanic Acid is not recommended for people who have a known cephalosporin allergy or who have Pseudomembranous Colitis.
Co-axet 250 Tablet Side Effects
Cefuroxime-Clavulanic Acid is generally well tolerated. However, nausea, vomiting, diarrhea, abdominal discomfort, or pain are possible adverse effects. Prolonged use of Cefuroxime and Clavulanic acid together, like other broad-spectrum antibiotics, can lead to nonsusceptible microorganism overgrowth. Renal failure, anaphylaxis, angioedema, pruritis, rash, and serum sickness, such as urticaria, can occur in a small percentage of patients (0.2 percent).
Pregnancy & Lactation
Antibiotics should be avoided if at all possible throughout the first trimester. Cefuroxime-Clavulanic Acid, on the other hand, can be safely used to treat urinary and other infections later in pregnancy. Cefuroxime-Clavulanic Acid is excreted in modest amounts in breast milk. However, the possibility of the newborn being sensitized should be considered.
Precautions & Warnings
Cefuroxime should be used with caution in individuals who are taking powerful diuretics and have a history of colitis.
Storage Conditions
Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.
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